Isithako esiphambili: Doxycycline hydrochloride

Iinkcazelo ngeempawu: Le mveliso iluhlaza okhanyayo.

Inyathelo lePharmacological:

Pharmacodynamics:Le mveliso yi-tetracycline ebanzi ye-antibiotic ene-antibacterial effect ebanzi. Iibhaktheriya ezinovakalelo ziquka iibhaktiriya zeGram-positive ezifana nepneumococcus, streptococcus, some staphylococcus, anthrax, tetanus, corynebacterium kunye nezinye iibhaktiriya ezingeGam-negative ezifana neEscherichia coli, Pasteurella, Salmonella, Brucella kunye neHaemophilus, Klebsiterella kunye ne-meliophilus. Kwakhona kunokuthintela i-Rickettsia, i-mycoplasma kunye ne-spirochaeta kwinqanaba elithile.

I-Pharmacokinetics:Ukufunxa ngokukhawuleza, impembelelo encinci ngokutya, i-bioavailability ephezulu. Ugxininiso lwegazi olusebenzayo lugcinwa ixesha elide, i-tissue permeability yomelele, ukusabalalisa kubanzi, kwaye kulula ukungena kwiseli. Umthamo obonakalayo wemeko yokuhanjiswa kwizinja malunga ne-1.5L/kg. Izinga eliphezulu lokubophelela kwiprotheyini kwizinja 75% ukuya kuma-86%. Inxalenye engasebenziyo nge-chelation emathunjini, i-75% yedosi yenja ikhutshwe ngale ndlela. Ukukhutshwa kwezintso kuphela malunga ne-25%, ukukhutshwa kwebiliary kungaphantsi kwe-5%. Isiqingatha sobomi benja malunga neeyure ezili-10 ukuya kwezi-12.

Ukudibana kweziyobisi:

(1) Xa ithathwa nge-sodium bicarbonate, inokunyusa ixabiso le-pH esiswini kunye nokunciphisa ukufunxa kunye nomsebenzi wale mveliso.

(2) Le mveliso inokwenza ii-complexes ezine-divalent kunye ne-trivalent cations, njl., Ngoko ke xa zithathwa kunye ne-calcium, i-magnesium, i-aluminium kunye nezinye i-antacids, iziyobisi ezine-iron okanye ubisi kunye nokunye ukutya, ukufunxa kwabo kuya kuncipha, kubangele ukunciphisa uxinzelelo lweziyobisi lwegazi.

(3) Ukusetyenziswa okufanayo kunye ne-diuretics enamandla efana ne-furthiamide kunokunyusa umonakalo wezintso.

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Iimpawu:

Ukusuleleka kweebhaktheriya ezintle, iibhaktheriya ezimbi kunye ne-mycoplasma. Izifo zokuphefumula (i-mycoplasma pneumonia, i-chlamydia pneumonia, i-feline nasal branch, isifo se-calicivirus, i-canine distemper). I-Dermatosis, inkqubo ye-genitourinary, usulelo lwesisu, njl.

Ukusetyenziswa kunye nedosi:

Doxycycline. Kulawulo lwangaphakathi: idosi enye, i-5 ~ 10mg nge-1kg ubunzima bomzimba wezinja kunye neekati. Isetyenziswe kanye ngosuku ngeentsuku ezi-3-5. Okanye njengoko kumiselwe ngugqirha. Kunconywa ukuthatha emva kokutya kunye nokusela amanzi amaninzi emva kokulawulwa komlomo.

Isilumkiso:

(1) Akukhuthazwa kwizinja kunye neekati ngaphantsi kweeveki ezintathu ngaphambi kokubeleka, ukuncelisa, kunye nenyanga eyi-1 ubudala.

(2) Sebenzisa ngokuqaphela kwizinja kunye neekati ezinesibindi esibi kunye nokungasebenzi kakuhle kwezintso.

(3) Ukuba ufuna ukuthatha izongezelelo ze-calcium, izongezelelo zentsimbi, iivithamini, i-antacids, i-sodium bicarbonate, njl. ngexesha elifanayo, nceda ubuncinane i-2h interval.

(4) Akuvumelekanga ukusebenzisa i-diuretics kunye ne-penicillin.

(5) Ukudibanisa ne-phenobarbital kunye ne-anticoagulant iya kuchaphazela umsebenzi womnye nomnye.

Impendulo engalunganga:

(1) Kwizinja kunye neekati, iziphumo ezibi kakhulu ze-doxycycline yomlomo kukuhlanza, uhudo, kunye nokunciphisa ukutya. Ukuze kuthomalaliswe iziphumo ezibi, akukho kuncipha kubalulekileyo ekufunxeni kweziyobisi kwabonwa xa kuthathwa kunye nokutya.

(2) I-40% yezinja eziphathwayo ziye zanda ukwanda kwe-enzymes enxulumene nomsebenzi wesibindi (i-alanine aminotransferase, i-conglutinase esisiseko). Ukubaluleka kweklinikhi kokunyuka komsebenzi wesibindi ezinxulumene ne-enzymes akucaci.

(3) I-doxycycline yomlomo ingabangela i-esophageal stenosis kwiikati, ezifana neepilisi zomlomo, kufuneka zithathwe ubuncinane nge-6ml yamanzi, ingomile.

(4) Unyango nge-tetracycline (ingakumbi ixesha elide) kunokukhokelela ekugqithiseni kweebhaktheriya ezingenabuhlungu okanye i-fungi (usulelo oluphindwe kabini).

Ekujoliswe kuko: Kuphela iikati nezinja.

Inkcazo: 200mg/ithebhulethi