Imidacloprid kunye neMoxidectin Spot-on Solutions (yeekati)

【Izithako】

Imidacloprid, iMoxidectin

【Imbonakalo】

Ulwelo olutyheli ukuya kontsundu.

Inyathelo lePharmacological:Iyeza le-Antiparasite. I-Pharmacodynamics:I-Imidacloprid sisizukulwana esitsha sezibulali-zinambuzane ezine-nicotine ezineklorini. Inobudlelwane obuphezulu be-postsynaptic nicotinic acetylcholine receptors kwinkqubo ye-nervous central yezinambuzane, kwaye inokuthintela umsebenzi we-acetylcholine, ekhokelela kukukhubazeka kwe-parasite kunye nokufa. Iyasebenza ngokuchasene neentakumba zabantu abadala kunye neentakumba ezincinci kumanqanaba ahlukeneyo, kwaye ikwabulala iintakumba ezincinci kwindalo esingqongileyo.

Indlela yokusebenza ye-moxidectin iyafana ne-abamectin kunye ne-ivermectin, kwaye inefuthe elihle le-kiling kwii-parasites zangaphakathi nangaphandle, ngakumbi i-nematodes kunye ne-arthropods. Ukukhutshwa kwe-asidi ye-butyric (GABA) kwandisa amandla ayo okubopha kwi-postsynaptic receptor, kwaye umjelo we-chloride uvula. I-Moxidectin nayo ine-selectivity kunye nobudlelwane obuphezulu be-glutamate mediated chloride ion channels, ngaloo ndlela iphazamisa ukuhanjiswa kwesignali ye-neuromuscular, ukuphumla kunye nokukhubazeka kwama-parasites, okukhokelela ekufeni kwee-parasites.

Iinhibitory interneurons kunye ne-excitatory motor neurons kwi-nematodes ziindawo zayo zesenzo, ngelixa kwi-arthropods iyindawo ye-neuromuscular junction. Indibaniselwano yezi zibini inefuthe le-synergistic. I-Pharmacokinet ics: Emva kokulawulwa kokuqala, imidacloprid yasasazwa ngokukhawuleza kumzimba wekati kwangolo suku lunye, kwaye yahlala phezu komzimba ngexesha lolawulo lweentsuku ezi-1-2 emva kokulawulwa, i-plasma concentration ye-moxidectin kwiikati ifikelela kwinqanaba eliphezulu. , kwaye isasazwa kuwo wonke umzimba kwinyanga enye kwaye i-metabolized kancinane kwaye ikhutshwe.

【Ukusetyenziswa kunye nethamo】

Le mveliso iboniswa kuthintelo kunye nonyango lwekwi vivokwayei-In vitro usulelo lwe-parasitic kwiikati. Le mveliso iboniswa kuthintelo kunye nonyango lwezifo zentakumba(Ctenocephalus felis), ukunyangwa kwezifo ze-ear mite(Pruritus auris), unyango losulelo lwe-nematode yesisu (abadala, abantu abadala abakhulileyo kunye nemibungu yesigaba se-L4Toxocarria feliskwayeHamnostoma tubuloides), ukukhuselwa kwe-filariasis ye-cardiac (i-L3 kunye ne-L4 yesigaba se-juveniles of heartworms). Kwaye inokunceda kunyango lwe-allergies dermatitis ebangelwa ziintakumba.

【Ukusetyenziswa kunye nethamo】

Ukusetyenziswa kwangaphandle. Idosi enye, ikati nge-1kg ubunzima bomzimba, i-10mg imidacloprid 1mg moxidectin, ilingana ne-0.1ml yale mveliso. Ngexesha le-prophylaxis okanye unyango, kucetyiswa ukuba ulawule kanye ngenyanga. Ukuthintela ukukhothwa, sebenzisa kuphela kwesikhumba emva kwentloko yekati kunye nentamo.

【Imiphumela】

1

(2) Emva kokulawulwa, ukuba isilwanyana sikhotha indawo yokulawula, iimpawu ze-neurological ezidlulayo zinokuvela ngamaxesha athile, ezifana nokuvuya, ukungcangcazela, iimpawu ze-ophthalmic (abafundi abahlanjululweyo, i-pupillary reflexes, kunye ne-nystagmus), ukuphefumla okungaqhelekanga, ukuhluma, kunye neempawu ezifana nokuhlanza. ;Utshintsho lokuziphatha ngamanye amaxesha olufana nokungafuni ukwenza umthambo, imincili, nokuphelelwa ngumdla wokutya.

【Ukulumkela】

(1)Ungasebenzisi amantshontsho angaphantsi kweeveki ezili-9 ubudala. Ungasebenzisi kwiikati ezingadibaniyo nale mveliso. Izinja ezikhulelweyo kunye nezanyisayo kufuneka zilandele iingcebiso zezilwanyana phambi kokuba zisetyenziswe.

(2)Iikati ezingaphantsi kwe-1kg kufuneka zilandele iingcebiso zonyango lwezilwanyana xa usebenzisa le mveliso.

(3)Kuyimfuneko ukuthintela iiCollies, ii-Old English Sheepdogs kunye neentlobo ezinxulumene nokukhotha le mveliso ngomlomo.

(4)Iikati ezigulayo kunye neekati ezinomzimba obuthathaka kufuneka zilandele iingcebiso zoogqirha bezilwanyana xa ziyisebenzisa.

(5)Le mveliso mayingasetyenziselwa izinja.

(6)Ngexesha lokusetyenziswa kwale mveliso, musa ukuvumela ichiza elikwityhubhu yeziyobisi ukuba liqhagamshelane namehlo kunye nomlomo wesilwanyana esilawulwayo okanye ezinye izilwanyana.Thintela izilwanyana eziphelelwe liyeza zikhothana. Musa ukubamba okanye unqumle iinwele de iyeza lome.

(7) Ngamaxesha athile i-1 okanye i-2 yokuvezwa kweekati emanzini ngexesha lolawulo ayiyi kuchaphazela kakhulu ukusebenza kwechiza. Nangona kunjalo, iikati ezihlala zihlamba ngeshampu okanye zifakwe emanzini zinokuchaphazela ukusebenza kwechiza.

(8)Gcina abantwana bangadibani nale mveliso.

(9)Musa ukugcina ngaphezulu kwe-30℃,kwaye ungasebenzisi ngaphaya komhla wokuphelelwa kweleyibhile.

(10)Abantu abangadibaniyo nale mveliso kufuneka bangayisebenzisi.

(11)Xa ufaka iyeza, umsebenzisi kufuneka akuphephe ukudibana nolusu, amehlo kunye nomlomo wale mveliso, kwaye angatyi, angaseli okanye atshaye; emva kolawulo, izandla kufuneka zihlanjwe. Ukuba kunjalo

Ichaphaze ngempazamo esikhumbeni, yihlambe ngesepha namanzi ngoko nangoko; ukuba ithe ngempazamo yachaphaza emehlweni, yihlambe ngamanzi kwangoko. Ukuba iimpawu aziphuculi, nceda uqhagamshelane nogqirha

imiyalelo.

(12) Okwangoku, akukho yeza likhethekileyo lokuhlangula le mveliso; ukuba iginywe ngempazamo, ilahle elifakwe ngomlomo linganceda ukukhupha ityhefu.

13 Ngaphambi kokuba indawo yokulawula yomile, thintela ezi zixhobo ukuba ziqhagamshelane nendawo yokulawula.

(14)Ungavumeli le mveliso ingene emanzini angaphezulu.

(15)Iziyobisi ezingasetyenziswanga kunye nezinto zokupakisha kufuneka zilahlwe ngendlela engenabungozi ngokweemfuno zendawo.

【Ixesha lokurhoxisa】Akukho nanye.

【Iinkcukacha】

(1)0.4ml:Imidacloprid 40mg+Moxidectin 4mg

(2)0.8ml:Imidacloprid 80mg +Moxidectin 8mg

【Ugcino】Itywinwe, igcinwe kwiqondo lokushisa.

【Beka ubomi kwishelufa】Iminyaka emi-3.