ImidaclopridkwayeI-MoxidectinIzisombululo zeSpot-on (zezinja)

【Isithako esiphambili】

Imidacloprid, iMoxidectin

【Imbonakalo】

Ulwelo olutyheli ukuya kontsundu.

【Pisenzo se-harmacologic】

Iyeza le-Antiparasite.

Pharmacodynamics:I-Imidacloprid sisizukulwana esitsha se-nicotine insecticide. Inobudlelwane obuphezulu be-postsynaptic nicotinic acetylcholine receptors kwinkqubo ye-nervous central yezinambuzane, kwaye inokuthintela umsebenzi we-acetylcholine, ekhokelela kwi-parasite ukukhubazeka nokufa. Isebenza ngokuchasene neentakumba zabantu abadala kunye neentakumba ezincinci kumanqanaba ahlukeneyo, kwaye inefuthe le-kiling kwiintakumba eziselula kwimekobume. Indlela yokusebenza ye-moxidectin ifana ne-abamectin kunye ne-ivermectin, kwaye inefuthe elihle le-kiling kwii-parasites zangaphakathi nangaphandle, ngakumbi i-nematodes kunye ne-arthropods. Ukukhutshwa kwe-asidi ye-butyric (GABA) kwandisa amandla ayo okubopha kwi-postsynaptic receptor, kwaye umjelo we-chloride uvula. I-Moxidectin nayo ine-selectivity kunye nobudlelwane obuphezulu be-glutamate-mediated chloride ion channels, ngaloo ndlela iphazamisa ukuhanjiswa kwesignali ye-neuromuscular, ukuphumla kunye nokukhubazeka kwama-parasites, okukhokelela ekufeni kwee-parasites. Iinhibitory interneurons kunye ne-excitatory motor neurons kwi-nematodes ziindawo zayo zesenzo, ngelixa kwi-arthropods yi-neuromuscular junction. Indibaniselwano yezi zibini inefuthe le-synergistic.

I-Pharmacokinetics:Emva kolawulo lokuqala, imidacloprid yasasazwa ngokukhawuleza kumzimba wenja kwangolo suku lunye, kwaye yahlala phezu komzimba ngexesha lexesha lolawulo lweentsuku ezi-4-9 emva kokulawulwa, ukuxinwa kwe-plasma ye-moxidectin ezinjeni ifikelela kwinqanaba eliphezulu, kwaye i-plasma ye-moxidectin ifikelela kwinqanaba eliphezulu. isasazwa kuwo wonke umzimba kwisithuba senyanga enye kwaye icotha i-metabolized kwaye ikhutshwe.

【Imiqondiso】
Ukuthintela kunye nokunyangwa kwezifo zangaphakathi nangaphandle ze-parasitic kwizinja. Uthintelo kunye nokunyangwa kweentakumba (Ctenocephalic canis), unyango lweentwala (Catonicus canis), unyango lwe-ear mite infestations (ltchy otica), canine sarcoids (Scabies mites), kunye ne-demodicosis (Demodex canis), kunyango lwe-Angiostrongylus kunye Usulelo lwe-nematode yesisu (abadala, i-aduts engekavuthwa kunye ne-L4imibungu ye-Toxocara canis, i-Ancylostoma canis, kunye ne-Ancylocephalus larvae;abadala be-Toxocara lionis kunye ne-Trichocephala vixensis). Kwaye inokusetyenziswa njengonyango lwe-adjuvant ye-alergic dermatitis ebangelwa ziintakumba.

【Ukusetyenziswa kunye nethamo】
Ukusetyenziswa kwangaphandle, lahla le mveliso eluswini ukusuka ngasemva kwenja phakathi kwamagxa amabini ukuya ezinqeni, kwaye uwahlule kwiindawo ezi-3-4. I-dose enye, kwizinja, nge-1kg yesisindo somzimba, i-10mg ye-imidacloprid kunye ne-2.5mg ye-moxidectin, elingana ne-0.1ml yale mveliso. Ngexesha lonyango lwe-prophylaxis, kucetyiswa ukuba ulawule kanye ngenyanga. Thintela izinja ekukhotheni.

【Imiphumela】

(1) Kwiimeko zomntu ngamnye, le mveliso inokubangela ukusabela okwaliwayo kwendawo, okubangela ukurhawuzelelwa okwethutyana, ukuncamathela kweenwele, i-erythema okanye ukugabha. Ezi mpawu ziyanyamalala ngaphandle konyango.

(2) Emva kokulawulwa, ukuba isilwanyana sikhotha indawo yokulawula, iimpawu ze-neurological ezidlulayo zinokuvela ngamanye amaxesha, ezifana nokuvuya, ukungcangcazela, iimpawu ze-ophthalmic (abafundi abahlanjululweyo, i-pupillary reflexes, kunye ne-nystagmus), ukuphefumla okungaqhelekanga, ukuhluma, kunye neempawu ezifana nokugabha. ; ngamanye amaxesha utshintsho oludlulayo lokuziphatha olufana nokungafuni ukwenza umthambo, imincili, kunye nokuphelelwa ngumdla.

【Ukulumkela】

(1)Ungasebenzisi iinjana ezingaphantsi kweeveki ezisi-7 ubudala. Izinja ezichasene nale mveliso akufanele ziyisebenzise. Izinja ezikhulelweyo kunye nezanyisayo kufuneka zilandele iingcebiso zezilwanyana phambi kokuba zisetyenziswe.

(2)Izinja ezingaphantsi kwe-1kg kufuneka zilandele iingcebiso zonyango lwezilwanyana xa usebenzisa le mveliso.

3imveliso ngomlomo.

(4)Izinja ezigulayo kunye nezinja ezinomzimba obuthathaka kufuneka zilandele iingcebiso zoogqirha bezilwanyana xa ziyisebenzisa.

(5)Le mveliso akufuneki isetyenziswe kwiikati.

6 Musa ukubamba okanye unqumle iinwele de iyeza lome.

(7) Ngamaxesha athile i-1 okanye i-2 yokuvezwa kwezinja emanzini ngexesha lolawulo ayiyi kuchaphazela kakhulu ukusebenza kweziyobisi. Nangona kunjalo, ukusetyenziswa rhoqo kweshampu xa uhlamba okanye ukucwina emanzini zizinja kunokuchaphazela ukusebenza kwechiza.

(8)Gcina abantwana bangadibani nale mveliso.

(9)Musa ukugcina ngaphezu kwama-30℃,kwaye ungasebenzisi ngaphaya komhla wokuphelelwa kweleyibhile.

(10)Abantu abangadibaniyo nale mveliso kufuneka bangayisebenzisi.

(11)Xa usebenzisa ichiza, umsebenzisi kufuneka akuphephe ukudibana nolusu, amehlo kunye nomlomo wale mveliso, kwaye angatyi, angaseli okanye atshaye; emva kokulawula, izandla kufuneka zihlanjwe. Ukuba ithe ngempazamo yatshiza eluswini, yihlambe ngesepha namanzi ngoko nangoko; ukuba ithe ngempazamo yachaphaza emehlweni, yihlambe ngamanzi ngoko nangoko.

(12) Okwangoku, akukho yeza likhethekileyo lokuhlangula le mveliso; ukuba iginywe ngempazamo, ilahle elifakwe ngomlomo linganceda ukukhupha ityhefu.

13 Ngaphambi kokuba indawo yolawulo yome, thintela ezi zixhobo ukuba ziqhagamshelane nendawo yolawulo

(14)Ungavumeli le mveliso ingene emanzini angaphezulu.

(15)Iziyobisi ezingasetyenziswanga kunye nezinto zokupakisha kufuneka zilahlwe ngendlela engenabungozi ngokweemfuno zendawo.

【Ukurhoxiswa  ixesha】Akukho nanye

【Inkcazo】

(1)0.4ml:Imidacloprid 40mg +Moxidectin 10mg

(2)1.0ml:Imidacloprid 100mg+Moxidectin 25mg

(3)2.5ml:Imidacloprid 250mg +Moxidectin 62.5mg

(4)4.0ml:Imidacloprid 400mg+Moxidectin 100mg

 【Ugcino】

Itywinwe, igcinwe kwiqondo lokushisa.

【Beka ubomi kwishelufa】

Iminyaka emi-3