Izinja ezifakwe i-spayid okanye i-neutered ziyacetyiswa ukuba azisetyenziselwa ukuzala. Kukho iingenelo ezintathu eziphambili ze-neutering:

1. Fokanye izinja zamabhinqa, i-neutering inokuthintela i-estrus, igweme ukukhulelwa okungafunekiyo, kwaye ithintele izifo zokuzala ezifana nezicubu zesifuba kunye ne-uterine pyogenesis. Kwizinja ezingamadoda, ukuthenwa kunokuthintela idlala lengqula, amatyhalarha kunye nezinye izifo zenkqubo yokuzala.
2. Ukuvala inzala kunokuthintela ukulwa, ubundlongo-ndlongo kunye nokunye ukuziphatha kakubi kunye nomngcipheko wokulahleka.
3. I-Neutering inokunciphisa inani lezilwanyana ezilahlekileyo. Ixesha elicetyiswayo lokunyathela liphambi kwe-estrus yokuqala kwizinja ezincinci kunye neziphakathi: iinyanga ezi-5-6 ubudala, iinyanga ezili-12 kwizinja ezinkulu. Umngcipheko onxulunyaniswa nokuvala inzala kukutyeba kakhulu, kodwa unokulawulwa ngokutyisa ukutya okwenziwa inzala ngokwenzululwazi.