I-Demenidazole, njengesizukulwana sokuqala samachiza ezinambuzane ze-antigenic, ixabiso layo eliphantsi lenza ukuba lisetyenziswe ngokubanzi kuxilongo lwezonyango lwezilwanyana kunye nonyango. Nangona kunjalo, ngokusetyenziswa ngokubanzi kolu hlobo lwamachiza kunye nesizukulwana esisemva kunye nesona sokuqala se-nitroimidazoles, ingxaki yokunganyangeki kwechiza kwisicelo ngokuqinisekileyo iya kuba ngakumbi kwaye ivele ngakumbi.

01Impembelelo ye-Anti-anaerobic

Nangona kunjalo, ukusetyenziswa kwayo ngokubanzi kwimveliso yeenkukhu kubonakaliswa ikakhulu kwiibhaktheriya ezilwa ne-anaerobic. Kwiminyaka emashumi edlulileyo, isetyenziswe ngokubanzi kunyango lwenkukhu ye-necrotic enteritis, i-enterotoxic syndrome kunye nokuvuvukala kwe-oviduct. Nangona kunjalo, uvakalelo lwayo kwi-anaerobes luya lusiba mbi ngakumbi. Isizathu kukuba: ixesha elide elidlulileyo, ukusetyenziswa kakubi kunye nokusetyenziswa okungaqhelekanga kuye kwakhokelela ekwandeni kokuchasana kweentlobo ezahlukeneyo zebhaktheriya ye-anaerobic kuyo unyaka nonyaka, kwaye ukubeka iliso kusaqhubeka. Ukuze kuthintelwe lo mkhwa umbi wophuhliso, isebe elinobuchule leyeza lezilwanyana liye layivala ngokucacileyo ngaphezu kweminyaka elishumi edlulileyo: inokusetyenziswa kuphela ekuzaleni nasekuveliseni ezona zilwanyana zisetyenziswa kakhulu ekutyeni, kwaye zinokusetyenziswa kuphela kwimveliso yezilwanyana. Ukuzalanisa imfuyo kunye neenkukhu, izilwanyana zasekhaya kunye nokunye ukungatya okukhethekileyo.

02Ukuhambelana kwezenzululwazi kunye nengqiqo

Kwinkalo yokuhambelana nokusetyenziswa ngokungekho ngqiqweni kwe-demenidazole, okokuqala, akufanele isetyenziswe kunye ne-methamphenicol, i-florfenicol kunye nezinye ii-antibiotics ze-alcohol ze-amido, kuba i-demenidazole inokubangela i-dysplasia yamathambo kwimfuyo kunye neenkukhu, kwaye xa isetyenziswa kunye noku kungasentla. i-amido alcohol antibiotics, iya kwandisa umngcipheko wokuphendula okungalunganga kwinkqubo yegazi.

Okwesibini, akufanele isetyenziswe kunye ne-ethanol okanye amalungiselelo aqulethe isixa esikhulu se-ethanol, kuba ukudibanisa kwezi zibini kuya kubangela ukusabela kwe-disulfiram, kunye nezilwanyana ezigulayo zinokuba neempawu ezithile zokuphazamiseka kwengqondo. Ukongeza, ukusetyenziswa kotywala okanye iziyobisi eziqulethe isixa esikhulu sotywala kufuneka kuncitshiswe kangangoko kunokwenzeka kwiintsuku ezingama-7-10 emva kokurhoxiswa kweziyobisi.

Okwesithathu, ngokukodwa kwishishini lezonyango zezilwanyana, okokuqala, akufanele zidibaniswe neziyobisi ze-immunosuppressive, ngaphandle koko, i-demenidazole inokuthintela umphumo we-mycophenolate mofetil emzimbeni. Okwesibini, ayinakusetyenziswa kunye ne-anticoagulants yomlomo, eya kuphucula umphumo we-anticoagulant ye-anticoagulants yomlomo efana ne-warfarin, ukwenzela ukuba izilwanyana zinomngcipheko wokuphuma kwegazi.

Okokugqibela, oku ikakhulu kwishishini lezonyango lwezilwanyana. Okokuqala, ayinakudityaniswa ne-inhibitors ye-enzyme yeziyobisi zesibindi. Ngokomzekelo, i-inhibitors ye-enzyme yeziyobisi yesibindi efana ne-cimetidine inokuthintela imetabolism ye-metronidazole. Xa kudityanisiwe, kuyimfuneko ukufumanisa i-concentration yeziyobisi zegazi kunye nokulungelelanisa umthamo ngokukhawuleza. Okwesibini kukuba ayinakusetyenziswa kunye ne-hepatic drug inducers inducers. Xa idibene ne-hepatic drug enzyme inducers efana ne-phenytoin, i-metabolism ye-demenidazole iya kukhawuleziswa kwaye i-concentration ye-plasma iya kuncitshiswa; I-metabolism ye-phenytoin kunye nezinye i-inducers ze-enzyme yeziyobisi ze-hepatic zancitshiswa kwaye ukuxinwa kwe-plasma kwanda.

03Ukulungiswa kuchaphazela umphumo wonyango

Ngenxa yokuba i-demenidazole ngokwayo i-soluble kancinane emanzini kwaye iyi-antibiotic exhomekeke kwixesha, iziphene zayo zamachiza kunye neempawu ze-pharmacodynamic zinquma ukuba "ulungiselelo lumisela ukusebenza". Sihlala sibona kwiiyunithi zengca ukuba ukunyibilika kwemveliso ye-dimenidazole premix kubi kakhulu. Emva kokongeza inani elikhulu lamanzi kunye nokuxuba ngokupheleleyo, kukho "inani elikhulu lezinto ezinganyibilikiyo" kwisampuli yesanti ecocekileyo. Oku asiko “sophistry” yomenzi ukubiza ingxaki yobulunga bamanzi, okanye ngobuxoki ukubanga ukuba izinto ezinganyibilikiyo zizincedisi kunye nezinye izithako ezingezizo iziyobisi.

Zonke iimveliso ezixubeneyo ze-dimenidazole, ukongeza kwixabiso eliphantsi kunye nexabiso eliphantsi, zimanyene "akukho siphumo".

Ngoko ke, uninzi lwamafama engca-ingcambu kunye nabasebenzisi amayeza wezilwanyana kufuneka ingqalelo “kwizinga eliphezulu” iimveliso ezinomxholo owaneleyo weziyobisi kunye ne-solubility efanelekileyo xa ukhetha iimveliso ze-dimenidazole premix kunyango lwezifo ze-anaerobic kwi-digestive tract okanye inkqubo yokuzala. Ukongeza ekukhethweni kwamachiza, elona nyathelo libalulekileyo yileli: ngokwenjongo yokwenyani yokwanda kokunganyangeki kumachiza, kufuneka senze umsebenzi olungileyo kwindibaniselwano, intsebenziswano kunye nokusetyenziswa ngokubambisana kokuchasana nokunganyangeki kumachiza, ukuze kwandiswe kwaye kubonakalise ukuxhathisa kumachiza. "ukusebenza" kunyango lweziyobisi.